PUBLICATIONS

-Timilsina, S.@, Kirsch-Mangu, T.*, Schuyler, W. *, Brooke, S. *, Tianle, M., Villa-Diaz, L.G.$  Enhanced self-renewal of human pluripotent stem cells by simulated microgravity. NPJ Microgravity 2022, 8:22. DOI:10.1038/s41526-022-00209-4.

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-Parson, T.M., Buelow, K.L., Hanna, A., Brake, M.A., Poma, C., Hosch, S.E., Westrick, R.J., Villa-Diaz, L.G., Wilson, G.D., Madlambayan, G.J.  Intratumoral hematopoietic stem and progenitor cell differentiation into M2 macrophages facilitates the regrowth of solid tumors after radiation therapy.  British Journal of Cancer 2022, 126:927-936.

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-Qiryaqoz, Z., Timilsina, S., Czarnowski, D, Krebsbach, P.H., Villa-Diaz, L.G.  Identification of biomarkers indicative of functional skeletal stem cells. Orthodontics & Craniofacial Research 2019 2 (Suppl. 1):192-198. DOI:10.111/ocr.12260

-Ramotowski, C,. Qu, X., Villa-Diaz, L.G.  Progress in the use of iPSCs for traumatic spinal cord injuries in animal populations: Meta-analysis and review. Stem Cell Translational Medicine 2019. DOI:10.1002/sctm.18-0225.

-Topal T., Kim, B.C., Villa-Diaz, L.G., Deng, C., Takayama, S., Krebsbach, P.H.  Rapid translocation of pluripotency-related transcription factors by external uniaxial forces.  Integrative Biology. 2019, 11:41-52. PMID: 30809641.

-Chen, W., Han, S., Qian, W., Weng, S., Yang, H., Sun, Y., Villa-Diaz, L.G., Krebsbach, P.H., Fu, J.  Nanotopography Regulates Motor Neuron Differentiation of Human Pluripotent Stem Cells. Nanoscale 2018, 10: 35563565.  PMID: 29410983.

-Villa-Diaz, L.G., Kim, J.K., Laperle, A. Palecek, S.P., Krebsbach, P.H.  Inhibition of Focal adhesion kinase signaling by integrin a6b1 supports human pluripotent stem cell self-renewal.  Stem Cells 2016, 34:1753-1764. PMID: 26930028.

-Qian, X., Kim, J.K. Tong, W., Villa-Diaz, L.G., Krebsbach, P.H.  DPPA5 promotes pluripotency and reprogramming by regulating NANOG turnover. Stem Cells 2016, 34:588-600.  PMID: 26661329.

-Villa-Diaz, L.G., Kim, J.K. Lahann, J., Krebsbach, P.H.  Derivation of xenogeneic-free and transgene-free human iPSCs on synthetic substrates.  Stem Cells Translational Medicine 2014. 3:1410-1417.  PMID: 25313201.

-Qian, X., Villa-Diaz, L.G., Kumar, R., Lahann, J., Krebsbach, P.H.  Enhancement of the propagation of human embryonic stem cells by modifications in the gel architecture of PMEDSAH polymer coatings.  Biomaterials 2014, 35:9581-9590.  PMID: 25189518.

-Jiang, G., Di Bernardo, J., Maiden, M., Villa-Diaz, L.G., Mabrouk, O., Krebsbach, P.H., O’Shea, K.S., Kunasaki, S.  Human transgene-free amniotic fluid-derived induced pluripotent stem cells for autologous treatment of prenatally diagnosed birth defects.  Stem Cells and Development 2014, 35:9581-9590.  PMID: 25014361.

-Sun, Y., Yong, K.M.A, Villa-Diaz, L.G., Zhang, X., Chen, W., Philson, R., Weng, S., Xu, H., Krebsbach, P.H., Fu., J.  Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells.  Nature Materials 2014, 13:599-604. PMID: 24728461.

-Sun, Y., Villa-Diaz, L.G., Lam, R.H.W, Chen, W., Krebsbach, P.H., Fu, J.  Mechanics regulates fate decisions of human embryonic stem cells.  PLoS ONE 2012, 7:e37178. PMID: 22615930.

-Chen, W., Villa-Diaz, L.G., Sun, Y., Weng, S., Kim, J.K., Lam, R.H.W., Han, L., Fan, R., Krebsbach, P.H., Fu, J. Nanotopography influences adhesion, spreading, and self-renewal of human embryonic stem cells.  ACS Nano 2012, 6:4094-4103. PMID: 22486594.

- Villa-Diaz, L.G., Brown, S.E., Liu, Y., Ross, A., Lahann, J., Parent, J.M., Krebsbach, P.H. Derivation of mesenchymal stem cells from human induced pluripotent stem cells cultured on synthetic substrates.  Stem Cells 2012, 30:1174-1181. PMID: 22415987.

- Nandivada, H.*, Villa-Diaz, L.G.*, O’Shea, K.S., Smith, G.D., Krebsbach, P.H., Lahann, J.  Fabrication of synthetic polymer coatings and their use in feeder-free culture of human embryonic stem cells.  Nature Protocols 2011, 6:1037-1043. PMID: 21720316.  *Equal authorship.

- Villa-Diaz, L.G.*, Nandivada H.*, Ding, J., Naiara C. Nogueira-de-Souza, Krebsbach, P.H., O’Shea, K.S., Lahann, J., Smith, G.D.  Synthetic polymer coatings for long-term growth of human embryonic stem cells. Nature Biotechnology 2010, 28: 581-583. PMID: 20512122. *Equal authorship.

- Villa-Diaz, L.G., Garcia-Perez, J.L., Krebsbach, P.H.  Enhanced transfection efficiency of human embryonic stem cells by the incorporation of DNA liposomes in extracellular matrix.  Stem Cells and Development 2010, 19:1949-1957. PMID: 20367256.

- Villa-Diaz, L.G., Torisawa, Y., Uchida, T., Ding, J., Nogueira-de-Souza, N.C., O'Shea, K.S., Takayama, S., Smith, G.D.  Microfluidic culture of single human embryonic stem cell colonies.  Lab Chip 2009, 9:1749-1755.  PMID: 19495459.

- Villa-Diaz, L.G., Pacut, C., Slawny, N. A., Ding, J., O'Shea, K. S., Smith, G. D.  Analysis of the factors that limit the ability of feeder-cells to maintain the undifferentiated state of human embryonic stem cells.  Stem Cells and Development 2009, 18:641-651. PMID: 18764735.

- Villa-Diaz, L.G., Miyano, T.  Activation of p38 MAPK during porcine oocyte maturation.  Biology of Reproduction 2004, 71:691-696. PMID: 15115730.

- Villa-Diaz, L.G., Barrell, G.K.  Involvement of serotoninergic pathways in the control of luteinizing hormone secretion in red deer hinds.  Reproduction, Fertility and Development 1999, 11: 95-103. PMID: 10735553.

Book Chapters and Reviews

- Bigoni-Ordoñez, G.B., Czarnowski, D., Parsons, T., Madlambayan, G.J., Villa-Diaz, L.G.  Integrin a6 (CD49f), the microenvironment and cancer stem cells. Current Stem Cell Research & Therapy, 2019; 14:428-436. doi: 10.2174/1574888X13666181002151330. PMID: 30280675

-Krebsbach, P.H., Villa-Diaz, L.G.  The role of integrin a6 (CD49f) in stem cells: more than a conserved biomarker.  Stem Cells and Development, 2017, 15:1090-1099. DOI: 10.1089/scd.2016.0319

-Jordahl, J.H., Villa-Diaz, L.G., Krebsbach, P.H., Lahann, J.  Engineered human stem cell microenvironments.  Curr Stem Cell Rep 2016, 2:73. DOI 10.1007/s40778-016-0035-7.

-Qian, X., Villa-Diaz, L.G., Krebsbach, P.H.  Advances in culture and manipulation of human pluripotent stem cells.  Journal of Dental Research 2013, 92:956-962. PMID: 239334156.

-Villa-Diaz, L.G., Ross, A.M., Lahann, J., Krebsbach, P.H.  Concise Review: The evolution of human pluripotent stem cell cultures: from feeder cells to synthetic coatings.  Stem Cells 2013, 31:1-7. PMID: 230081828.

-Scheller, E.L., Villa-Diaz, L.G., Krebsbach, P.H.  Gene therapy: implications for craniofacial regeneration.  Journal of Craniofacial Surgery 2012, 23:333-337. PMID: 22337437

-Smith, G.D., Villa-Diaz, L.G.  Oocytes. Potential developmental consequences of cryopreservation of mammalian oocytes and embryos.  In “Vitrification in Assisted Reproduction: A User’s Manual and Troubleshooting Guide”.  Liebermann, J and Tucker, M.J. (eds.), published by Taylor & Francis Books Ltd.  2007.

-Villa-Diaz, L.G., Miyano, T.  The extracellular regulated kinase, MAPK in porcine oocytes during maturation.  In “Animal Frontier Sciences”.  Sato, E., Miyamoto, H. and Manabe, N. (eds.), Hokuto Shobo, Kyoto, Japan, 2003. 

Thesis:

PhD Thesis

-Timilsina, S., Villa-Diaz, L.G.  The role of CD49f -Integrin a6- in human stem cell biology. Ph.D. Dissertation October 2021.

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          Master of Science in Biology thesis:

-Crozier, J., Villa-Diaz, L.G.  Identification and isolation of cardiac stem cells derived from human pluripotent stem cells. 2019.

-Czarnowski, D.F., Villa-Diaz, L.G.  Hypoxia modulates the expression of CD49f in human embryonic stem cells. 2019.

          Honors College thesis:

-Bradford, J., Villa-Diaz, L.G.  Mapping human retina organoids for investigating whole retina regeneration. 2022.

-Kozlowski, P., Villa-Diaz, L.G.  CD49f: A novel regulatory axis of human cardiogenesis. 2022.

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-Kirsh Mangu, T., Villa-Diaz, L.G. Determining the role of focal adhesion kinase in the nucleus of human pluripotent stem cells.

-Deban, C., Villa-Diaz, L.G.  Interpreting the roles of integrin-linked kinase (ILK) in self-renewal of pluripotent stem cells. 2021

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-Werth, S., Villa-Diaz, L.G.  Designing a miniature bioreactor to assist with culturing miniature brains derived from human pluripotent stem cells. 2019.

-Qiryaqoz, Z., Villa-Diaz, L.G.  Characterization of skeletal stem cells via novel biomarkers. 2019.

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-Ramotowski, C., Villa-Diaz, L.G.  Progress in the use of induced pluripotent stem cells for cervical and thoracic traumatic spinal cord injuries: Meta-analysis and Review. 2018.

-Howe, C., Villa-Diaz, L.G.  Elucidating the role of integrin alpha-6 in cardiomyocytes differentiated from human pluripotent stem cells. 2018.

-Wilber, G., Villa-Diaz, L.G.  An investigation of the role of integrin alpha6 in human induced pluripotent stem cell development and pluripotency. 2017.